Sexual Health
Introducing Verrutop For Sexual Health
Verrutop has been regularly used in a number of European settings for several years and whilst much of the published clinical data spans all aspects of HPV wart therapy from a dermatological perspective there have been a number of standalone reports looking specifically at ano-genital warts which bolster the specific use of Verrutop in this field.
The most recent study, a single blinded RCT post-dates the publication of the EADV Position document.
Verrutop has an impressive and increasing range of clinical studies to support its introduction.
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Verrutop: included in recent Position Statement
Treatment: Nitric–zinc complex topical solution
Mode of action: Induces a caustic effect on the wart through mummification and protein denaturation/coagulation action
Schedule: Once or up to four times; repeat at 2-week intervals if needed
Clearance rate (%): 90–99
Recurrence rate (%): Not evaluated
Advantages: Efficacy, Easy application
Disadvantages: Current evidence in AGW available from a limited number of patients only, Investigation of recurrence rate is required
Clinical Papers
Treatment of External Condylomas: a retrospective analysis of more than 100 patients treated with an original nitric-zinc and organic acid complex in Belgium and Hungary.
Duray E & Blouard B. Poster. 26th EADV Geneva. 13-17 Sep 2017
- Dual centre retrospective study of 100 patients with external anogenital warts in 2 centres in Belgium and Hungary
- Product applied to each visible condyloma every 2 weeks for a maximum of 4 sessions
- Efficacy defined by 3 level scale measured 2 weeks after last application
Treatment was well tolerated (slight pain, burning sensation during treatment, minimal post-treatment itching, no blistering, no post-treatment pain, and no wound formation.)
results
- Belgian cohort
- 94% of patients had complete cure after a maximum of 3 sessions
- 88.2% were successfully cured after 2 sessions
- 64.7% were successfully cured in just 1 treatment session
- Hungarian cohort
- 91.2% of treated patients were totally cured after a maximum of 4 treatments, once every two weeks
- 84.5 % were successfully cured after 3 sessions
- 77.8 % were successfully cured after 2 sessions
- 48.9% were successfully cured in just 1 treatment session
- 6.7% of patients showed only a partial improvement of their external anogenital warts
A Multicentre, Randomised Clinical Trial to Compare a Topical Nitrizinc Complex Solution Versus Cryotherapy for the Treatment of Anogenital Warts
Pontini P, Mastorino L, Gaspari V, Granger C, Ramoni S, Delmonte S, Evangelista V, Cusini M. 2020
- RCT. Single blinded study Vs Cryotherapy
- 120 patients
- Maximum of 4 treatments
Results
- Complete clearance in 89.7% of the Verrutop group compared with 75.4% in the Cryo group (p=0.0443)
- Recurrences after 1 month 18.4% in Verrutop group vs 38.1% of the cryo group (p=0.0356)
- Recurrences after 3 months 25% of Verrutop group vs 40.6% of cryo group (p=0.149)
Conclusions
Nitrizinc Complex solution can be considered to be as effective as CRYO for the treatment of small (
“We hope that the results of this comparative study will support the inclusion of NZCS as treatment for AGW in future treatment guidelines”
Efficacy Assessment of a Topically Applied Nitric-Zinc Complex Solution for the Treatment of External Anogenital Warts in 100 Patients
Ciccarese G, Drago F, Granger C, Parodi A. 2019
- 100 patients with 418 Ano-Genital warts
- Retrospective Cohort Study
- Verrutop applied every 2 weeks for a maximum of 5 sessions
Efficacy
A wart cure rate of 92% was observed in ≤ 4 treatment sessions (383 lesions cured), with a cure rate of 49% with only one application
Complete clearance was observed in 84% of patients
Safety
The treatment was well tolerated by most patients
Follow-up
Relapses were observed in 29% of patients at 3 months and in 5% at 6 months
For more information or to arrange a face to face meeting (or virtual meeting) please call us on 01462 346100 or email chris@esperehealth.co.uk
To Order
Verrutop 4x0.1ml ampoule pack can be ordered directly from Espère Healthcare Ltd by calling us on 01462 346100 and we will deliver within 24-48 hours.
Alternatively, Verrutop is listed under the NHS Supply Chain Sexual Health Framework using NPC code FPH053
